Taking any dose of any non-aspirin non-steroidal anti-inflammatory drug (NSAID) early in pregnancy may more than double the risk of a spontaneous miscarriage are the conclusions of a study published recently in the Canadian Medical Association Journal (CMAJ)
“Given that the use of nonaspirin NSAIDs during early pregnancy has been shown to increase the risk of major congenital malformations1 and that our results suggest a class effect on the risk of clinically detected spontaneous abortion, nonaspirin NSAIDs should be used with caution during pregnancy.”
The Royal College of Midwives and the Royal Pharmaceutical Society are now advising against the use of non-aspirin NSAIDs during pregnancy.
However a recent study published in June 2012 in Obstetrics & Gynecology says that women who use over the counter nonsteroidal anti-inflammatory drugs during early pregnancy are at no increased risk for spontaneous abortion but do note that previous studies of prescription NSAIDs have found a connection between NSAIDs and spontaneous abortion. Prescription NSAIDS may be at higher doses than over the counter NSAIDS.